David Warner is locked in to open in the fourth Ashes Test, but Australia could leave out spinner Todd Murphy in order to play both Mitch Marsh and Cameron Green in the same side.
Captain Pat Cummins said in Tuesday's pre-match press conference Australia had finalised their XI for Old Trafford, but would wait to tell players before announcing the side.
Cummins did, however, confirm Warner would play after a week of speculation about his future, while Josh Hazlewood would return in place of Scott Boland.
But he was coy on whether Green would return, after he missed the third Test at Headingley with a hamstring complaint and fellow allrounder Mitch Marsh scored a century in his place.
If both Marsh and Green do play, it would be through Australia going without a frontline spinner with Murphy the man to be squeezed out.
"Josh will come in for Scott Boland, and the top order will stay the same," Cummins said.
"Part of the conversation is how do two allrounders fit in, is spin going to be important this week?"
"Davey (Warner) didn't have his best game last week at Headingley, but prior to that, he has looked really good.
"He has had three 50-run (opening) partnerships, which can be rare over in England."
Murphy was only used for 9.3 overs across two innings at Headingley, and Travis Head spent as much time bowling spin in the nets as Murphy at training on Monday.
Australia have not gone without a frontline spinner since the WACA Test against India in January 2012, with the vast majority of the 117 matches since then including the now-injured Nathan Lyon.
But Cummins insisted he would be comfortable entering a Test without a spinner if required.
Playing into the debate is that rain is forecast for days four and five at Old Trafford, while cloudy skies and rain have persisted in the lead up to the Test - conditions generally favourable to seam.
"Every situation is different," Cummins said.
"We’ve played games with one quick, we’ve played some games with heaps of quicks. It’s all really conditions-based.
"As I said last week about Toddy, I would have loved to bowl him a bit more but there wasn’t a heap of overs in the game, the ball seemed to swing and seam a little bit.
"So that’s certainly something to weigh up this week."
Cummins' comments came as England captain Ben Stokes said he would always prefer to enter Old Trafford with a spinner.
The ground has traditionally turned, however there has been less on offer for tweakers since they turned the square around 90 degrees in 2010.
"Generally I find here the ball does tend to spin towards the back end of a game, so it's always nice having the option there," Stokes said.
"We played here last year against South Africa and we found our seamers were a little bit more impactful.
"But you do find the ball tends to spin towards the back end of Test matches here. Whether or not it will because of the weather around, who knows.
"But I think every team you do want to have the option there."
